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泛亚电竞app:刘晓晔

[发表时间]:2022-09-01 [浏览次数]:


刘晓晔,女,汉族,中共党员,2018年于中国农业大学获得农学博士学位,随后博士后进入北京大学工学院学习,方向为生物医学工程。20217月进入泛亚电竞app,基础兽医学,兽医药理与毒理学方向,主要科研方向为宿主导向的抗菌药物研发,耐药性/耐受性机制研究,天然中草药及方剂的抗菌机制研究,柔性基底水凝胶筛药体系研究;讲授的课程包括《兽医药理学》、《兽药创制与应用》、《动物细胞生物学》、《动物毒理学》等。联系方式:xiaoyeliu@bua.edu.cnxiaoyeliu@pku.edu.cn

科研学习经历

1)、2018.09 – 2021.07,北京大学,生物医学工程,博士后

2)、2014.09 - 2018.06,中国农业大学,兽医药理与毒理学,博士

3)、2011.09 - 2014.06,泛亚电竞app,中兽医,硕士

4)、2007.09 - 2011.06,西南大学,动物医学,本科

主要工作业绩:

从事耐药菌防控工作已经近十年时间,长期致力于细菌耐药/耐受性机制,耐药性防控策略,以及宿主导向的抗菌药物研发工作,对宿主细胞,细菌和抗菌药物三者之间的相互作用方式有系统的研究工作。一作或通讯作者发表SCI论文10篇;中科院1区,IF>10分的top期刊文章有3篇,相关研究成果在Trends in Microbiology,Advanced Science, Biomaterials上以封面形式报道;在畜牧兽医杂志,中国兽医杂志,中国动物传染病学报等杂志上以一作和通讯作者发表中文核心9篇;申请专利5项,2项已授权。在Tranditianal Medicine ResearchZoonoses杂志上担任青年编委,担任BioArtMED公众号编辑。主持中国科协青年智库项目,北京市青年基金面上项目,研究生优秀课程建设教改项目。

科研成果如下:

SCI文章

1) Liu. X., Wu. Y., Mao. C., Shen. J., Zhu. K.*, Host-acting antibacterial compounds combat cytosolic bacteria. Trends Microbiol. 2022, doi: 10.1016/j.tim.2022.01.006. IF = 17.079, Q1

2) He. S., Deng. Q., Liang. B., Yu. F., Yu. X., Guo. D., Liu. X.*, Dong. H.*, Suppressing alpha-hemolysin as potential target to screen of flavonoids to combat bacterial coinfection. Molecules, 2021, 26, 7577. IF = 4.47, Q2

3) Liu,X., Zhu, K., Wang, P., Duan, X., Peng, W., Zhang, Y., Huang, J*, Extracellular matrix stiffness modulates bacterial invasion and antibiotic therapy. Biomaterials. 2021, 277, 121098. IF = 12.479, Q1

4) Liu, X., Zhang, Y., Li, Z., Zhang, P., Wu, Y. *, Sun, Y*. Paeoniflorin Derivative in Paeoniae Radix aqueous extract suppresses alpha-toxin of Staphylococcus aureus. Front. Microbiol. 2021, 12, 649390. IF=5.640, Q2

5) Liu, X, Liu, F., Ding, S., Shen, J.*, Zhu, K.*, Sublethal levels of antibiotics promote bacterial persistence in epithelial cells. Adv. Sci. 2020, 7, 1900840. IF = 16.806, Q1 封面文章

6) Liu, X.*, Zhang, H., He, S., Mu, X., Hu, G*, Dong, H*. Endothelial-derived interleukin-1alpha activates innate immunity by promoting the bactericidal activity of transendothelial neutrophils. Front. Cell. Dev. Biol. 2020, 8, 590. IF = 6.684, Q2

7) Liu, X.*, He, S., Li Q., Mu, X., Hu, G, Dong, H*. Comparison of the gut microbiota between Pulsatilla decoction and levofloxacin hydrochloride therapy on Escherichia coli infection. Front. Cell. Infect. 2020, 10, 319. IF = 5.293, Q2

8) Liu, X., Hu, Q., Xu, F., Ding, S., Zhu, K.*, Characterization of Bacillus cereus in the dairy products in China. Toxins. 2020, 12, 454 IF = 4.546, Q2

9) Liu, X., Ding, S., Shi, P., Dietrich, R., Martlbauer, E., and Zhu, K., Non-hemolytic enterotoxin of Bacillus cereus induces apoptosis in Vero cells. Cell Microbiol. 2017, 19, doi:10.1111/cmi.12684. IF = 4.2, Q2

10) Liu, X., Dong, H.*, Wang, M., Gao, Y., Zhang, T., Hu, G., Duan, H., and Mu, X.*, IL-1alpha-induced microvascular endothelial cells promote neutrophil killing by increasing MMP-9 concentration and lysozyme activity. Immunol Res, 2016, 64(1): 133-142.2. IF = 2.8, Q3

11) Cui, Y., Liu, X., Dietrich, R., Martlbauer, E., Cao, J., Ding, S., and Zhu, K.*, Characterization of Bacillus cereus isolates from local dairy farms in China. FEMS Microbiol Lett. 2016, 363(12), doi: 10.1093/femsle/fnw096. IF = 1.9, Q3

12) Cui, Y., Liu, Y., Liu, X., Xia, X., Ding, S., and Zhu, K.*, Evaluation of the Toxicity and toxicokinetics of cereulide from an emetic Bacillus cereus strain of milk origin. Toxins. 2016, 8(6), doi: 10.3390/toxins8060156. IF = 3.8, Q2

13) Ying, L., Fei, L., Zhang, J., Liu, X., Xiao, P., Bai, H., Chen, S., Wang, D., Simon H.P., Ryan T.K., Shen, J., Kui, Z.*, and Tang B.*, Efficient killing of multidrug - resistant internalized bacteria by AIEgens in vivo. Adv. Sci. 2021, 8, 2001750. IF = 16.806, Q1


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